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Aranesp® (darbepoetin alfa)

Policy Number: PH-0242

Subcutaneous/Intravenous

*NON-DIALYSIS*

Last Review Date: 05/04/2023

Date of Origin: 10/17/2008

Dates Reviewed: 11/2008, 06/2009, 12/2009, 09/2010, 12/2010, 02/2011, 03/2011, 06/2011, 08/2011, 09/2011, 12/2011, 03/2012, 06/2012, 09/2012, 10/2012, 12/2012, 03/2013, 05/2013, 06/2013, 09/2013, 12/2013, 03/2014, 06/2014, 09/2014, 12/2014, 03/2015, 05/2015, 08/2015, 11/2015, 02/2016, 05/2016, 08/2016, 11/2016, 02/2017, 04/2017, 8/2017, 11/2017, 02/2018, 05/2018, 04/2019, 04/2020, 09/2020, 05/2021, 05/2022, 05/2023

Precertification requirements do not apply for this policy. Pre-payment claim edits are applied to diagnosis criteria within this policy.

 

FOR PEEHIP Members Only -Coverage excludes the provider-administered medication(s) outlined in this drug policy from being accessed through a specialty pharmacy. It must be obtained through buy and bill.

  1. Length of Authorization
  • Coverage will be provided for 45 days and may be renewed.
  1. Dosing Limits

A. Quantity Limit (max daily dose) [NDC unit]:

  • Aranesp 10 mcg prefilled syringe: 1 syringe up to every 7 days
  • Aranesp 25 mcg vial or prefilled syringe: 1 vial or syringe up to every 7 days
  • Aranesp 40 mcg vial or prefilled syringe: 1 vial or syringe up to every 7 days
  • Aranesp 60 mcg vial or prefilled syringe: 1 vial or syringe up to every 7 days
  • Aranesp 100 mcg vial or prefilled syringe: 1 vial or syringe up to every 7 days
  • Aranesp 150 mcg prefilled syringe: 1 syringe up to every 7 days
  • Aranesp 200 mcg vial or prefilled syringe: 1 vial or syringe up to every 7 days
  • Aranesp 300 mcg vial or prefilled syringe: 1 vial or syringe up to every 14 days (MPN may be as frequent as every 7 days)
  • Aranesp 500 mcg prefilled syringe: 1 syringe up to every 14 days

B. Max Units (per dose and over time) [HCPCS Unit]:

  • MDS (J0881 only): 500 billable units every 14 days
  • MPN (J0881 only): 300 billable units every 7 days
  • CKD (Non-Dialysis Patients):
    • Initial: 100 billable units every 14 days
    • Maintenance: 600 billable units every 28 days
  • Chemotherapy-induced: 600 billable units every 21 days
  1. Initial Approval Criteria 1,4,5

Coverage is provided in the following conditions:

  • Patient is at least 18 years of age (unless otherwise specified); AND
  • Initiation of therapy Hemoglobin (Hb) < 10 g/dL and/or Hematocrit (Hct) < 30%; AND

Universal Criteria 1,3,16,18

  • Lab values are obtained within 30 days of the date of administration (unless otherwise indicated); AND
  • Patient has adequate iron stores as demonstrated by serum ferritin ≥ 100 ng/mL (mcg/L) and transferrin saturation (TSAT) ≥ 20% (measured within the previous 3 months for renewal)*; AND
  • Other causes of anemia (e.g. hemolysis, bleeding, vitamin deficiency, etc.) have been ruled out; AND
  • Patient does not have uncontrolled hypertension; AND

Anemia Due to Myelodysplastic Syndrome (MDS) ‡ 2,4

  • Patient has symptomatic anemia; AND
    • Patient has lower risk disease (defined as IPSS [Low/Intermediate-1]); AND
      • Used as a single agent for del(5q) mutation (excluding use in patients with cytogenetic abnormality involving chromosome 7); OR
    • Patient has lower risk disease (defined as IPSS-R [Very Low, Low, Intermediate]); AND
      • Patient does not have del(5q) mutation; AND
            • Patient has a serum erythropoietin (EPO) ≤ 500 mU/mL; AND
                • Patient has ring sideroblasts < 15% (or <5% with an SF3B1 mutation); AND
              • Used as a single agent; OR
              • Used in combination with either lenalidomide or a granulocyte-colony stimulating factor (G-CSF) following no response (despite adequate iron stores) or erythroid response followed by loss of response to an erythropoiesis-stimulating agent (ESA) alone; OR
                • Patient has ring sideroblasts ≥15% (or ring sideroblasts ≥5% with an SF3B1 mutation); AND
              • Used as a single agent; OR
              • Used in combination with a G-CSF

Anemia Due to Myeloproliferative Neoplasms (MPN) - Myelofibrosis ‡ 2,5

  • Endogenous serum erythropoietin level of < 500 mUnits/mL

Anemia Due to Chemotherapy Treatment † 1-3

  • Patient is receiving concomitant myelosuppressive chemotherapy for a non-myeloid malignancy; AND
  • Patient’s chemotherapy is not intended to cure their disease (i.e., palliative treatment); AND
  • There are a minimum of two additional months of planned chemotherapy

Anemia Due to Chronic Kidney Disease (Non-Dialysis Patients) † 1,16,18

  • Patient at least 1 month of age

FDA Approved Indications; Compendia Recommended Indication(s); Ф Orphan Drug

  1. Renewal Criteria 1,4,5

Coverage can be renewed based upon the following criteria:

  • Patient continues to meet universal and other indication-specific relevant criteria identified in section III; AND
  • Previous dose was administered within the past 60 days; AND
  • Disease response with treatment as defined by improvement in anemia compared to pretreatment baseline; AND
  • Absence of unacceptable toxicity from the drug. Examples of unacceptable toxicity include: pure red cell aplasia, severe allergic reactions (anaphylaxis, angioedema, bronchospasm, etc.), severe cardiovascular events (stroke, myocardial infarction, congestive heart failure, thromboembolism, etc.), uncontrolled hypertension, seizures, increased risk of tumor progression/recurrence in patients with cancer, severe cutaneous reactions (erythema multiforme, Stevens-Johnson Syndrome [SJS]/Toxic Epidermal Necrolysis [TEN], etc.), etc.; AND

Anemia Due to Myelodysplastic Syndrome (MDS):

  • Hemoglobin (Hb) < 12 g/dL and/or Hematocrit (Hct) < 36%

Anemia Due to Myeloproliferative Neoplasms (MPN) – Myelofibrosis:

  • Hemoglobin (Hb) < 10 g/dL and/or Hematocrit (Hct) < 30%

Anemia Due to Chemotherapy Treatment:

  • Refer to Section III for criteria

Anemia Due to Chronic Kidney Disease (Non-Dialysis Patients):

  • Pediatric patients: Hemoglobin (Hb) < 12 g/dL and/or Hematocrit (Hct) < 36%
  • Adult patients: Hemoglobin (Hb) < 11 g/dL and/or Hematocrit (Hct) < 33%

* Intravenous iron supplementation may be considered when evaluating iron status

  • Functional iron deficiency (i.e., adequate iron stores with an insufficient supply of available iron) may occur in patients with chronic diseases, cancer, and/or in those currently receiving ESAs.
  • Iron is not generally recommended in anemic patients with a Ferritin >500 ng/mL.
  • Anemic patients with a Ferritin ≤500 ng/mL AND TSAT <50% may derive benefit from IV iron therapy in conjunction with ESA.
  1. Dosage/Administration 1,3-5,7,17

Indication

Dose

Anemia due to chemotherapy §

Initial Dose:

Administer 2.25 mcg/kg subcutaneously every 7 days

-OR-

Administer 500 mcg subcutaneously every 21 days

Maximum Dose:

May increase up to 4.5 mcg/kg subcutaneously every 7 days for insufficient response

Anemia due to Chronic Kidney Disease – Non-dialysis §

Initial Dose in Adult and Pediatric Patients:

Administer 0.45 mcg/kg intravenously or subcutaneously every 28 days

-OR-

Administer 0.75 mcg/kg intravenously or subcutaneously every 14 days

Maximum Dose:

Adult patients: May increase to a maximum dose of 600 mcg every 28 days

Pediatric patients: Dose will not exceed maximum initial dosing indicated above

Anemia due to MDS §

Initial Dose:

Administer 150 to 300 mcg subcutaneously every 14 days

Maximum Dose:

May increase up to 500 mcg every 14 days

Anemia due to MPN §

Initial Dose:

Administer 150 mcg subcutaneously every 7 days

Maximum Dose:

May increase up to 300 mcg every 7 days

§

  • For patients with CKD:
  • Dose increases of 25% can be considered if after 4 weeks of initial therapy the hemoglobin has increased less than 1 g/dL and the current hemoglobin level is less than the indication specific level noted above.
  • Dose decreases of 25% or more can be considered if the hemoglobin rises rapidly by more than 1 g/dL in any 2-week period.
  • Dose and frequency requested are the minimum necessary for the patient to avoid RBC transfusions.
  • Avoid frequent dose adjustments. Do not increase the dose more frequently than once every 4 weeks; decreases can occur more frequently.
  • If patients fail to respond over a 12-week dose escalation period, further dose increases are unlikely to improve response and discontinuation of therapy should be considered.
  • For patients with MDS:
  • After 3 to 4 months of therapy, if there is no response as measured by at least a 1.5 g/dL increase in hemoglobin or a decrease in RBC transfusions, discontinuation of therapy should be considered.
  • For patients with MPN:
  • After 3 months of therapy, if there is no response as measured by at least a 2 g/dL increase in hemoglobin or a decrease in RBC transfusions, discontinuation of therapy should be considered.
  • For patients on Cancer Chemotherapy:
  • After 8 weeks of therapy, if there is no response as measured by hemoglobin levels or if RBC transfusions are still required or following completion of a chemotherapy course discontinue therapy.
  1. Billing Code/Availability Information

HCPCS code:

  • J0881 – Injection, darbepoetin alfa, 1 microgram (non-ESRD use); 1 billable unit = 1 mcg

NDC:

Single-dose Vial

Single-dose Prefilled Syringe

1 Vial/Pack, 4 Packs/Case

1 Syringe/Pack, 4 Packs/Case

200 mcg/1 mL

 55513-0006-xx

200 mcg/0.4 mL

 55513-0028-xx

300 mcg/1 mL

 55513-0110-xx

300 mcg/0.6 mL

 55513-0111-xx

500 mcg/1 mL

 55513-0032-xx

4 Vials/Pack, 10 Packs/Case

4 Syringes/Pack, 10 Packs/Case

25 mcg/1 mL

 55513-0002-xx

10 mcg/0.4 mL

 55513-0098-xx

40 mcg/1 mL

 55513-0003-xx

25 mcg/0.42 mL

 55513-0057-xx

60 mcg/1 mL

 55513-0004-xx

40 mcg/0.4 mL

 55513-0021-xx

100 mcg/1 mL

 55513-0005-xx

60 mcg/0.3 mL

 55513-0023-xx

100 mcg/0.5 mL

 55513-0025-xx

150 mcg/0.3 mL

 55513-0027-xx

  1. References
  1. Aranesp [package insert] Thousand Oaks, CA; Amgen Inc; January 2019. Accessed April 2023.
  2. Referenced with permission from the NCCN Drugs & Biologics Compendium (NCCN Compendium®) darbepoetin alfa. National Comprehensive Cancer Network, 2023. The NCCN Compendium® is a derivative work of the NCCN Guidelines®. NATIONAL COMPREHENSIVE CANCER NETWORK®, NCCN®, and NCCN GUIDELINES® are trademarks owned by the National Comprehensive Cancer Network, Inc. To view the most recent and complete version of the Compendium, go online to NCCN.org. Accessed April 2023.
  3. Referenced with permission from the NCCN Drugs & Biologics Compendium (NCCN Compendium®) Hematopoietic Growth Factors – Management of Cancer-and Chemotherapy-Induced Anemia Version 2.2023. National Comprehensive Cancer Network, 2023. The NCCN Compendium® is a derivative work of the NCCN Guidelines®. NATIONAL COMPREHENSIVE CANCER NETWORK®, NCCN®, and NCCN GUIDELINES® are trademarks owned by the National Comprehensive Cancer Network, Inc. To view the most recent and complete version of the Compendium, go online to NCCN.org. Accessed April 2023.
  4. Referenced with permission from the NCCN Drugs & Biologics Compendium (NCCN Compendium®) Myelodysplastic Syndrome Version 1.2023. National Comprehensive Cancer Network, 2023. The NCCN Compendium® is a derivative work of the NCCN Guidelines®. NATIONAL COMPREHENSIVE CANCER NETWORK®, NCCN®, and NCCN GUIDELINES® are trademarks owned by the National Comprehensive Cancer Network, Inc. To view the most recent and complete version of the Compendium, go online to NCCN.org. Accessed April 2023.
  5. Referenced with permission from the NCCN Drugs & Biologics Compendium (NCCN Compendium®) Myeloproliferative Neoplasms Version 3.2022. National Comprehensive Cancer Network, 2023. The NCCN Compendium® is a derivative work of the NCCN Guidelines®. NATIONAL COMPREHENSIVE CANCER NETWORK®, NCCN®, and NCCN GUIDELINES® are trademarks owned by the National Comprehensive Cancer Network, Inc. To view the most recent and complete version of the Compendium, go online to NCCN.org. Accessed April 2023.
  6. Younossi ZM, Nader FH, Bai C, et al. A phase II dose finding study of darbepoetin alpha and filgrastim for the management of anaemia and neutropenia in chronic hepatitis C treatment. Journal of Viral Hepatitis 2008; 15(5):370-8.
  7. Cervantes F, Alvarez-Laran A, Hernandez-Boluda JC, et al. Darbepoetin-alpha for the anaemia of myelofibrosis with myeloid metaplasia. British Journal of Haematology, 134: 184–186. doi:10.1111/j.1365-2141.2006.06142.x.
  8. Andre JL, Deschenes G, Boudaillies B, et al, “Darbepoetin, Effective Treatment of Anaemia in Paediatric Patients With Chronic Renal Failure,” Pediatr Nephrol, 2007, 22(5):708-14.
  9. Canon JL, Vansteenkiste J, Bodoky G, et al, “Randomized, Double-Blind, Active-Controlled Trial of Every-3-Week Darbepoetin Alfa for the Treatment of Chemotherapy-Induced Anemia,” J Natl Cancer Inst, 2006, 98(4):273-84.
  10. Bristoyiannis G, Germanos N, Grekas D, et al, “Unit Dosing of Darbepoetin Alfa for the Treatment of Anemia in Patients With End-Stage Renal Disease Being Switched From Recombinant Human Erythropoietin: Results of a Phase IIIb, 27-Week, Multicenter, Open-Label Study in Greek Patients,” Curr Ther Res, 2005, 66(3):195-211.
  11. Gabrilove J, Paquette R, Lyons RM, et al. Phase 2, single-arm trial to evaluate the effectiveness of darbepoetin alfa for correcting anaemia in patients with myelodysplastic syndromes. Br J Haematol. 2008;142(3):379-393.
  12. Park S, Fenaux P, Greenberg P, et al. Efficacy and safety of darbepoetin alpha in patients with myelodysplastic syndromes: a systematic review and meta-analysis. Br J Haematol 2016;174(5):730-747. Doi: 10.1111/bjh.14116.
  13. Park S, Greenberg P, Yucel A, et al. Clinical effectiveness and safety of erythropoietin-stimulating agents for the treatment of low- and intermediate-1-risk myelodysplastic syndrome: a systematic literature review. Br J Haematol. 2019;184(2):134-160. doi: 10.1111/bjh.15707.
  14. Toto RD, Pichette V, Brenner R, et al, “Darbepoetin Alfa Effectively Treats Anemia in Patients With Chronic Kidney Disease With de novo Every-Other-Week Administration,” Am J Nephrol, 2004, 24(4):453-60.
  15. Warady BA, Arar MY, Lerner G, et al, “Darbepoetin Alfa for the Treatment of Anemia in Pediatric Patients With Chronic Kidney Disease,” Pediatr Nephrol, 2006, 21(8):1144-52.
  16. Kidney Disease: Improving Global Outcomes (KDIGO) Anemia Work Group. KDIGO clinical practice guideline for anemia in chronic kidney disease. Kidney Int Suppl. 2012;2(suppl):279-335. https://kdigo.org/guidelines/anemia-in-ckd/. Published August 2012.
  17. Pfeffer MA, Burdmann EA, Chen CY, et al; TREAT Investigators. A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med. 2009 Nov 19;361(21):2019-32. doi: 10.1056/NEJMoa0907845.
  18. Mikhail A, Brown C, Williams JA, et al. Renal association clinical practice guideline on Anaemia of Chronic Kidney Disease. BMC Nephrol. 2017 Nov 30;18(1):345. doi: 10.1186/s12882-017-0688-1.
  19. Wisconsin Physicians Service Insurance Corporation. Local Coverage Determination (LCD): Erythropoiesis Stimulating Agents (ESAs) (L34633). Centers for Medicare & Medicaid Services, Inc. Updated on 06/22/2021 with effective dates 07/01/2021. Accessed April 2023.
  20. CGS Administrators, LLC. Local Coverage Determination (LCD): Erythropoiesis Stimulating Agents (ESA) (L34356). Centers for Medicare & Medicare Services. Updated on 02/23/2023 with effective dates 03/02/2023. Accessed April 2023.
  21. National Coverage Determination (NCD) for Erythropoiesis Stimulating Agents (ESAs) in Cancer and Related Neoplastic Conditions (110.21). Centers for Medicare & Medicaid Services, Inc. Updated on 01/14/2021 with effective dates 07/30/2007. Accessed April 2023.
  22. Wisconsin Physicians Service Insurance Corporation. Local Coverage Article (LCA): Billing and Coding: Erythropoiesis Stimulating Agents (ESAs) (A56795). Centers for Medicare & Medicaid Services, Inc. Updated on 10/18/2022 with effective dates 10/01/2022. Accessed April 2023.
  23. CGS Administrators, LLC. Local Coverage Article (LCA): Billing and Coding: Erythropoiesis Stimulating Agents (ESA) (A56462). Centers for Medicare & Medicaid Services. Updated on 02/28/2023 with effective dates 03/09/2023. Accessed April 2023.
  24. Palmetto GBA. Local Coverage Article (LCA): Billing and Coding: Erythropoiesis Stimulating Agents (ESA) (A58982). Centers for Medicare & Medicaid Services. Updated on 08/18/2022 with effective dates 10/01/2022. Accessed April 2023.

Appendix 1 – Covered Diagnosis Codes

ICD-10

ICD-10 Description

C93.10

Chronic myelomonocytic leukemia, not having achieved remission

C94.40

Acute panmyelosis with myelofibrosis not having achieved remission

C94.41

Acute panmyelosis with myelofibrosis in remission

C94.42

Acute panmyelosis with myelofibrosis in relapse

C94.6

Myelodysplastic disease, not classified

D46.0

Refractory anemia without ring sideroblasts, so stated

D46.1

Refractory anemia with ring sideroblasts

D46.20

Refractory anemia with excess of blasts, unspecified

D46.21

Refractory anemia with excess of blasts 1

D46.4

Refractory anemia, unspecified

D46.9

Myelodysplastic syndrome, unspecified

D46.A

Refractory cytopenia with multilineage dysplasia

D46.B

Refractory cytopenia with multilineage dysplasia and ring sideroblasts

D46.C

Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality

D46.Z

Other myelodysplastic syndromes

D47.1

Chronic myeloproliferative disease

D47.4

Osteomyelofibrosis

D63.0

Anemia in neoplastic disease

D63.1

Anemia in chronic kidney disease

D64.81

Anemia due to antineoplastic chemotherapy

D64.9

Anemia unspecified

D75.81

Myelofibrosis

I12.9

Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease

I13.0

Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease

I13.10

Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease

N18.30

Chronic kidney disease, stage 3 (moderate), unspecified

N18.31

Chronic kidney disease, stage 3a

N18.32

Chronic kidney disease, stage 3b

N18.4

Chronic kidney disease, stage 4 (severe)

N18.5

Chronic kidney disease, stage 5

N18.9

Chronic kidney disease, unspecified

Z51.11

Encounter for antineoplastic chemotherapy

Z51.89

Encounter for other specified aftercare

Dual coding requirements:

  • Anemia due to CKD (not on dialysis): must bill D63.1 AND I12.9, I13.0, I13.10, N18.30, N18.31, N18.32, N18.4, or N18.9
  • Anemia due to Chemotherapy: must bill D64.81 or D61.810 AND C-series, D-series or Q-series coding for NON-myeloid malignancies
  • Anemia due to MDS: must bill D47.3 AND D75.81

Appendix 2 – Centers for Medicare and Medicaid Services (CMS)

Medicare coverage for outpatient (Part B) drugs is outlined in the Medicare Benefit Policy Manual (Pub. 100-2), Chapter 15, §50 Drugs and Biologicals. In addition, National Coverage Determination (NCD), Local Coverage Articles (LCAs), and Local Coverage Determinations (LCDs) may exist and compliance with these policies is required where applicable. They can be found at: https://www.cms.gov/medicare-coverage-database/search.aspx. Additional indications may be covered at the discretion of the health plan.

Medicare Part B Covered Diagnosis Codes (applicable to existing NCD/LCA/LCD):

 

 

Jurisdiction(s): ALL

NCD/LCD/LCA Document (s): 110.21

https://www.cms.gov/medicare-coverage-database/new-search/search-results.aspx?keyword=110.21&areaId=all&docType=NCA%2CCAL%2CNCD%2CMEDCAC%2CTA%2CMCD%2C6%2C3%2C5%2C1%2CF%2CP

 

Jurisdiction(s): 5, 8

NCD/LCD/LCA Document (s): L34633

https://www.cms.gov/medicare-coverage-database/new-search/search-results.aspx?keyword=l34633&areaId=all&docType=NCA%2CCAL%2CNCD%2CMEDCAC%2CTA%2CMCD%2C6%2C3%2C5%2C1%2CF%2CP

Jurisdiction(s): 15

NCD/LCD/LCA Document (s): L34356

https://www.cms.gov/medicare-coverage-database/new-search/search-results.aspx?keyword=l34356&areaId=all&docType=NCA%2CCAL%2CNCD%2CMEDCAC%2CTA%2CMCD%2C6%2C3%2C5%2C1%2CF%2CP

 

Jurisdiction(s): 5, 8

NCD/LCD/LCA Document (s): A56795

https://www.cms.gov/medicare-coverage-database/new-search/search-results.aspx?keyword=a56795&areaId=all&docType=NCA%2CCAL%2CNCD%2CMEDCAC%2CTA%2CMCD%2C6%2C3%2C5%2C1%2CF%2CP

Jurisdiction(s):  15

NCD/LCD/LCA Document (s): A56462

https://www.cms.gov/medicare-coverage-database/new-search/search-results.aspx?keyword=a56462&areaId=all&docType=NCA%2CCAL%2CNCD%2CMEDCAC%2CTA%2CMCD%2C6%2C3%2C5%2C1%2CF%2CP

Jurisdiction(s):  J,M

NCD/LCD/LCA Document (s): A58982

https://www.cms.gov/medicare-coverage-database/search-results.aspx?keyword=a58982&areaId=all&docType=NCA%2CCAL%2CNCD%2CMEDCAC%2CTA%2CMCD%2C6%2C3%2C5%2C1%2CF%2CP.

Medicare Part B Administrative Contractor (MAC) Jurisdictions

Jurisdiction

Applicable State/US Territory

Contractor

E (1)

CA, HI, NV, AS, GU, CNMI

Noridian Healthcare Solutions, LLC

F (2 & 3)

AK, WA, OR, ID, ND, SD, MT, WY, UT, AZ

Noridian Healthcare Solutions, LLC

5

KS, NE, IA, MO

Wisconsin Physicians Service Insurance Corp (WPS)

6

MN, WI, IL

National Government Services, Inc. (NGS)

H (4 & 7)

LA, AR, MS, TX, OK, CO, NM

Novitas Solutions, Inc.

8

MI, IN

Wisconsin Physicians Service Insurance Corp (WPS)

N (9)

FL, PR, VI

First Coast Service Options, Inc.

J (10)

TN, GA, AL

Palmetto GBA, LLC

M (11)

NC, SC, WV, VA (excluding below)

Palmetto GBA, LLC

L (12)

DE, MD, PA, NJ, DC (includes Arlington & Fairfax counties and the city of Alexandria in VA)

Novitas Solutions, Inc.

K (13 & 14)

NY, CT, MA, RI, VT, ME, NH

National Government Services, Inc. (NGS)

15

KY, OH

CGS Administrators, LLC

 

 

 

ARANESP (darbepoetin alfa) Non-Dialysis

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